All Tone2 products are compatible with OSX 10.11 El Capitan and working as exspected.
However many other audio companies experience critical problems. Some of them, especially if they are related to older products, might remain unsolved. The problems with El Capitan seem to be related to drivers, permissions and missing runtime libraries.
I've heard that Apple is working on a fix from their side. When it will be released and if it will solve the compatibility problems is unknown.
So far we do not recommend the upgrade to El Capitan if you are using audio software.